This article provides a review of how polyvinyl chloride and acrylic plastisols can be utilized as adhesives and sealants. Plastisols are liquid dispersions of a finely divided thermoplastic resin, generally polyvinyl chloride or acrylic resin, in a plasticizer. These resulting pastes are highly viscous mixtures that on heating become homogenized so that a single solid phase results. When cooled, the plastisol provides a tough material with good physical characteristics. Over the years these inexpensive plastisol materials have become popular as both adhesives and sealants. Plastisols have been used primarily as gap fillers and sealants in automobiles and consumer appliances. However, these unique products have also found their way into several building and construction applications. This article provides a review of how polyvinyl chloride and acrylic plastisols can be utilized as adhesives and sealants.