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Technion Invents Seal-V, a Glue Which Retains its Sealant Capacity Even on Wet Surfaces

Published on 2013-12-05. Author : SpecialChem

Internal incisions are tricky. Unlike exterior cuts, internal ones are constantly surrounded by fluids, a fact that renders many adhesives useless. When Professor Havazelet Bianco-Peled looked for a solution to this problem, she thought it might come from a place that's always wet - under the sea - and she was right.

Since the early 2000s, Bianco-Peled has been researching the adhesion mechanism of algae to rocks underwater, and her research has proven fruitful. After unveiling the chemical composition of the algae adhesive, Bianco-Peled proceeded to create a synthetic adhesive that imitates the binding mechanism and chemical composition of algae.

Under the sealant

Sealantis, a private start-up from the Technion, Israel's Institute of Technology, established by Bianco-Peled in 2007, announced in early October that they received the CE mark for Seal-V, their vascular surgery sealant. Sealantis develops seamless incision technology that mechanically seals areas of potential leakage after surgery, without the need for sutures, which are not always effective sealants.

The algae-mimetic technology allows Seal-V to retain its sealant capacity even on wet surfaces. "Sealing surgical incisions requires sticking to wet or moist surfaces, which is a challenge that most known adhesives can't usually meet," explains Bianco-Peled.

As simple as one-two

Seal-V technology is based on the dual components of an Alginate Pre-Gel, a solution developed from the cell walls of brown algae, and a Curing Mesh, which acts to harden the pre-gel solution, creating effective binding of the open area. The application process requires the surgeon to first cover the wounded area with the pre-gel, and only then apply the curing mesh using an applicator. The pre-gel solution hardens within the space of a minute.

This two-staged approach allows the surgeon to ensure that the binding solution is in the desired position before it hardens, thus avoiding surgical complications. Moreover, the gel is dyed blue for visualization to guarantee the wound is entirely covered.

Unlike hemostats, which are normally used for sealing incisions and require blood clotting for the sealing process, Seal-V is an effective adhesive regardless of the presence of blood. Seal-V is also biorestorbable, meaning that it will be automatically absorbed by the body after the wound is healed.

Shooting for FDA approval

Tomer Fuchs, Sealantis CEO, has said about the recent CE marking: "We are excited to be able to introduce Seal-V to the European market and to provide surgeons with a new and better option for controlling bleeding from suture-lines."

About Technion Technology Transfer

Technion Technology Transfer (T3) office is your gateway to the state-of-the-art in scientific and technological innovation at Technion, Israel. Combining knowledge of emerging market needs with updated information on new developments and discoveries,T³ assists in finding the most promising projects, accompanying you in every step of technology transfer.

Source: Technion Technology Transfer


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